Description

3,5-Difluoro-4-(Methylsulfonyl)Phenol is a high-purity fluorinated phenolic compound featuring a methylsulfonyl substituent, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in providing a versatile, functionalized aromatic scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors who require reliable, high-quality building blocks for their synthesis pipelines.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the difluoro and sulfonyl groups contribute to biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic cores used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated phenolic units into polymer chains, enhancing properties like chemical resistance, thermal stability, and surface characteristics.
• Cross-Coupling Reactions: The phenolic OH and halogen substituents make it a valuable substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Chemical Research & Development: A versatile reagent for academic and industrial research exploring new fluorinated compounds and their physicochemical properties.

Basic Information

Product Name	3,5-Difluoro-4-(Methylsulfonyl)Phenol
CAS No.	1447123-15-0
Molecular Formula	C7H6F2O3S
Molecular Weight	208.18 g/mol
Synonyms	4-(Methylsulfonyl)-3,5-difluorophenol; 3,5-Difluoro-4-(methanesulfonyl)phenol; 3,5-Difluoro-4-methylsulfonylphenol; 2,6-Difluoro-4-hydroxy-1-(methylsulfonyl)benzene; Phenol, 3,5-difluoro-4-(methylsulfonyl)-; 1447123-15-0; 4-Hydroxy-2,6-difluorophenyl methyl sulfone
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-4-(Methylsulfonyl)Phenol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical and agrochemical applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, and we support customer audits and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.