Description

3,5-Difluoro-4-(Methythio)Phenol is a high-purity fluorinated phenolic compound with a methylthio substituent, serving as a critical advanced intermediate in modern organic synthesis. Its unique structure, combining fluorine atoms and a sulfur-containing group, makes it a valuable building block for creating molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process developers in the pharmaceutical and agrochemical industries for applications in drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, where the difluoro and methylthio groups contribute to bioactivity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Acts as a monomer or additive to introduce fluorine and sulfur functionalities into specialty polymers, enhancing their chemical resistance and surface properties.
• Cross-Coupling Reactions: An essential substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl and heteroaryl structures.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating compound libraries for high-throughput screening in various chemical fields.

Basic Information

Product Name	3,5-Difluoro-4-(Methythio)Phenol
CAS No.	1447123-13-8
Molecular Formula	C7H6F2OS
Molecular Weight	176.19 g/mol
Synonyms	4-(Methylthio)-3,5-difluorophenol; 3,5-Difluoro-4-methylsulfanylphenol; Phenol, 3,5-difluoro-4-(methylthio)-; 4-Methylmercapto-3,5-difluorophenol; 3,5-Difluoro-4-(methylmercapto)phenol; 3,5-Difluoro-4-(methylsulfanyl)phenol; CAS 1447123-13-8
EINECS	Contact for details

Quality Control

Our production of 3,5-Difluoro-4-(Methythio)Phenol adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical syntheses. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 99.0% (High Purity Grade)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.