Description

Fmoc-3-Chloro-n-Methyl-L-Phenylalanine CAS NO 1446478-28-9 is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing specific structural modifications, such as chlorination and N-methylation, into peptide backbones to enhance metabolic stability and binding affinity. It is an essential building block for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy synthesis of complex peptides.
• Pharmaceutical Research & Development: Used in the discovery and development of new peptide-based drugs, including protease inhibitors and receptor agonists/antagonists.
• Peptidomimetic Design: Incorporates chlorinated and N-methylated motifs to improve the pharmacological properties of lead compounds.
• Chemical Biology & Proteomics: Serves as a tool for studying protein-protein interactions and enzyme mechanisms through modified peptide substrates.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening.
• API Intermediate Manufacturing: Acts as a critical chiral intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fmoc-3-Chloro-n-Methyl-L-Phenylalanine
CAS No.	1446478-28-9
Molecular Formula	C25H22ClNO4
Molecular Weight	435.90 g/mol
Synonyms	Fmoc-3-chloro-N-methyl-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-chloro-N-methyl-L-phenylalanine; Fmoc-3-Cl-N-Me-L-Phe-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]-3-(3-chlorophenyl)propanoic acid; N-Fmoc-3-chloro-N-methyl-L-phenylalanine; Fmoc-N-Me-3-Cl-Phe-OH; N-α-Fmoc-N-methyl-3-chloro-L-phenylalanine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-3-Chloro-n-Methyl-L-Phenylalanine is produced under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot, confirming compliance with customer specifications and research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.