Description

n-α-Fmoc-n-δ-Methyl-L-Glutamine is a protected, non-proteinogenic amino acid derivative designed for advanced peptide synthesis. This compound matters for its role as a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of a modified glutamine residue with a methyl group on the delta nitrogen. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing novel peptide-based therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled assembly of complex peptides.
• Pharmaceutical Research: Synthesis of peptide drug candidates, including potential enzyme inhibitors or receptor modulators containing modified glutamine analogs.
• Bioconjugation & Probe Development: Used to introduce a uniquely functionalized amino acid handle for labeling or cross-linking studies.
• Combinatorial Chemistry Libraries: Generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Biochemical Research: Studying protein structure-function relationships and enzyme specificity by incorporating non-natural amino acids.

Basic Information

Product Name	n-α-Fmoc-n-δ-Methyl-L-Glutamine
CAS No.	1446478-17-6
Molecular Formula	C22H24N2O5
Molecular Weight	396.44 g/mol
Synonyms	Fmoc-Gln(Me)-OH; Fmoc-Nδ-Methyl-L-glutamine; Nα-Fmoc-Nδ-methyl-L-glutamine; (2S)-5-(Methylamino)-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-oxopentanoic acid; N-Fmoc-N'-methyl-L-glutamine; Fmoc-L-Gln(Me)-OH; Nα-(9-Fluorenylmethoxycarbonyl)-Nδ-methyl-L-glutamine
EINECS	Contact for details

Quality Control

Our n-α-Fmoc-n-δ-Methyl-L-Glutamine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee compliance with research and cGMP-grade standards for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.