Description

Fmoc-His-Aib-Oh Tfa is a specialized, orthogonally protected dipeptide building block used in solid-phase peptide synthesis (SPPS). This compound is critical for introducing the unique structural constraint of the non-proteinogenic amino acid Aib (α-aminoisobutyric acid) adjacent to a histidine residue, which can influence peptide conformation and biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical tools, where precise sequence control and high purity are paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the sequential assembly of complex peptides containing Aib and histidine.
• Peptidomimetic Drug Discovery: For creating constrained peptide analogs with enhanced metabolic stability, bioavailability, and target specificity.
• Antimicrobial Peptide (AMP) Research: In the design and synthesis of novel AMPs where Aib incorporation can stabilize helical structures.
• Bioconjugation and Probe Development: The Fmoc-protected N-terminus allows for controlled deprotection and further functionalization of synthetic peptides.
• Structural Biology Studies: To investigate the role of Aib in inducing or stabilizing specific secondary structures like 310- or α-helices in peptide models.
• GPCR Ligand Synthesis: For producing peptide ligands targeting G-protein-coupled receptors, where histidine often plays a crucial role in binding.

Basic Information

Product Name	Fmoc-His-Aib-Oh Tfa
CAS No.	1446013-08-6
Molecular Formula	C31H31F3N6O7
Molecular Weight	656.61 g/mol
Synonyms	Fmoc-His(Aib)-OH·TFA; N-α-Fmoc-N-π-trityl-L-histidyl-α-aminoisobutyric acid trifluoroacetate; Fmoc-L-His(Trt)-Aib-OH·TFA; Fmoc-His(Trt)-Aib-OH TFA salt; 9-Fluorenylmethyloxycarbonyl-L-histidyl-α-aminoisobutyric acid trifluoroacetate; Fmoc-His(Trt)-α-aminoisobutyric acid·TFA; Fmoc-H(Aib)-OH·TFA
EINECS	Contact for details

Quality Control

Every batch of Fmoc-His-Aib-Oh Tfa is manufactured and tested under strict quality management systems. We guarantee high chemical purity and consistency, supported by comprehensive analytical data including HPLC, MS, and NMR. A Certificate of Analysis (COA) detailing purity, identity, and specific impurity profiles is provided with each shipment to ensure it meets the exacting standards required for advanced peptide research and cGMP-guided synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive); allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.