Description

Fmoc-His-Aib-Oh CAS NO 1446013-07-5 is a protected amino acid derivative, specifically an Fmoc-protected dipeptide featuring the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib). This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptide sequences. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide therapeutics, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated, stepwise construction of custom peptide chains, particularly those requiring the Aib residue.
• Peptidomimetic Drug Discovery: Incorporation of the Aib residue to induce specific conformational constraints (e.g., helical stabilization) in synthetic peptides, enhancing their metabolic stability and biological activity.
• Research & Development: Synthesis of reference standards, bioactive peptide fragments, and novel peptide-based materials for academic and industrial R&D.
• Pharmaceutical Intermediates: Production of active pharmaceutical ingredients (APIs) for peptide-based drugs targeting various therapeutic areas.
• Bioconjugation & Labeling: Used in the preparation of peptide conjugates for diagnostic imaging, targeted drug delivery, and biochemical assays.

Basic Information

Product Name	Fmoc-His-Aib-Oh
CAS No.	1446013-07-5
Molecular Formula	C27H29N5O6
Molecular Weight	519.55 g/mol
Synonyms	Fmoc-His-Aib-OH; Fmoc-L-Histidyl-2-aminoisobutyric acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-histidyl-2-aminoisobutyric acid; Fmoc-His-Aib; Fmoc-His-Aib-OH (Aib = 2-aminoisobutyric acid); Nα-Fmoc-Nim-protected histidyl-aminoisobutyric acid; Fmoc-His(Trt)-Aib-OH (if side-chain protected); Peptide synthesis building block Fmoc-His-Aib
EINECS	Contact for details

Quality Control

Our Fmoc-His-Aib-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral integrity is provided with every shipment to guarantee reproducible performance in your applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.