Description

6-Amino-3-Bromo-2-(Trifluoromethyl)Phenol, also known as 4-Bromo-2-hydroxy-3-(trifluoromethyl)aniline, is a high-value halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine and trifluoromethyl substituents on an aromatic amine/phenol scaffold, makes it indispensable for creating complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Chemistry: Acts as an intermediate for synthesizing complex, high-performance dyes and pigments, especially azo dyes, where it contributes to color fastness and unique hues.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Buchwald-Hartwig) to construct biaryl and other complex architectures.
• Ligand and Catalyst Development: Utilized to create novel chelating ligands for metal catalysts used in asymmetric synthesis and other specialized chemical transformations.

Basic Information

Item	Details
Product Name	6-Amino-3-Bromo-2-(Trifluoromethyl)Phenol / 4-Bromo-2-Hydroxy-3-(Trifluoromethyl)Aniline
CAS No.	1445995-79-8
Molecular Formula	C7H5BrF3NO
Molecular Weight	256.02 g/mol
Synonyms	4-Bromo-2-hydroxy-3-(trifluoromethyl)aniline; 2-Amino-4-bromo-6-(trifluoromethyl)phenol; 6-Bromo-2-amino-3-(trifluoromethyl)phenol; 3-Bromo-6-amino-2-(trifluoromethyl)phenol; 4-Bromo-2-amino-α,α,α-trifluoro-m-cresol; 2-Hydroxy-3-(trifluoromethyl)-4-bromoaniline; 4-Bromo-2-hydroxy-3-trifluoromethylphenylamine; 1445995-79-8
EINECS	Contact for details

Quality Control

Our 6-Amino-3-Bromo-2-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.