Description

1-(2-Fluoro-6-Hydroxyphenyl)-2,2,2-Trifluoroethan-1-One, 3-Fluoro-2-(Trifluoroacetyl)Phenol is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a phenolic hydroxyl and a trifluoroacetyl group, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, where the introduction of fluorine atoms is a key strategy to modulate bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in kinase inhibitors, anti-inflammatory agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where fluorine substitution enhances efficacy and environmental stability.
• Material Science Precursor: Serves as a building block for fluorinated polymers, liquid crystals, and organic electronic materials requiring specific optical or electronic properties.
• Chemical Research & Development: Employed in academic and industrial labs for method development, catalysis studies, and exploring new fluorination chemistry.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses producing bespoke fluorinated compounds for client projects.

Basic Information

Product Name	1-(2-Fluoro-6-Hydroxyphenyl)-2,2,2-Trifluoroethan-1-One, 3-Fluoro-2-(Trifluoroacetyl)Phenol
CAS No.	1445995-75-4
Molecular Formula	C8H4F4O2
Molecular Weight	208.11 g/mol
Synonyms	3-Fluoro-2-(trifluoroacetyl)phenol; 2',6'-Difluoro-2-hydroxyacetophenone (trifluoromethyl analog); 1-(2-Fluoro-6-hydroxyphenyl)-2,2,2-trifluoroethanone; 2-Hydroxy-3-fluorophenyl trifluoromethyl ketone; α,α,α-Trifluoro-2-fluoro-6-hydroxyacetophenone; TFAP-F derivative; Fluorinated trifluoroacetylphenol
EINECS	Contact for details

Quality Control

Our production of 1-(2-Fluoro-6-Hydroxyphenyl)-2,2,2-Trifluoroethan-1-One adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and scale-up applications. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.