Description

Boc-(R)-2-Amino-5-Methylhexanoic Acid is a high-purity, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group on the amine functionality. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering excellent stability and selectivity in solid-phase and solution-phase peptide coupling reactions. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic tools, and advanced biomaterials.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Peptide Synthesis: Used in Fmoc/t-Boc solid-phase peptide synthesis (SPPS) for the controlled incorporation of the (R)-2-amino-5-methylhexanoic acid residue into peptide chains.
• Proteomics Research: Employed in the design and synthesis of custom peptides for studying protein-protein interactions, enzyme kinetics, and cellular signaling pathways.
• Bioconjugation: Acts as a linker or spacer molecule in the creation of peptide-drug conjugates (PDCs) and other bioconjugates for targeted drug delivery systems.
• Chemical Biology Tool: Utilized to introduce stable, non-hydrolyzable amino acid analogs into peptides to probe structure-activity relationships (SAR) and enhance metabolic stability.
• Reference Standard: Functions as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Boc-(R)-2-Amino-5-Methylhexanoic Acid
CAS No.	1445976-44-2
Molecular Formula	C₁₂H₂₃NO₄
Molecular Weight	245.32 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-5-methylhexanoic acid; (R)-N-Boc-2-Amino-5-methylhexanoic acid; Boc-D-2-Amino-5-methylhexanoic acid; N-(tert-Butoxycarbonyl)-D-2-amino-5-methylhexanoic acid; Boc-D-Leucine analog; tert-Butyl (R)-(5-methyl-1-carboxy-1-oxopentan-2-yl)carbamate
EINECS	Contact for details

Quality Control

Our Boc-(R)-2-Amino-5-Methylhexanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with research and pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.