Description

2-Chloro-4-isopropoxy-5-nitropyrimidine is a high-purity, functionalized pyrimidine building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate, enabling the construction of complex molecular architectures through selective substitution reactions. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential kinase inhibitors and herbicides.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and plant growth regulators.
• Material Science Research: Serves as a precursor for functionalized heterocyclic compounds used in organic electronic materials.
• Chemical Biology Probes: Utilized in the creation of tagged molecules for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring specific pyrimidine substitution patterns.

Basic Information

Product Name	2-Chloro-4-isopropoxy-5-nitropyrimidine
CAS No.	1445894-94-9
Molecular Formula	C7H8ClN3O3
Molecular Weight	217.61 g/mol
Synonyms	5-Nitro-2-chloro-4-isopropoxypyrimidine; 2-Chloro-4-(1-methylethoxy)-5-nitropyrimidine; 4-Isopropoxy-2-chloro-5-nitropyrimidine; 1445894-94-9; Pyrimidine, 2-chloro-4-(1-methylethoxy)-5-nitro-; 2-Chloro-4-propan-2-yloxy-5-nitropyrimidine
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-isopropoxy-5-nitropyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.