Description

6-Chloro-1-(Tetrahydro-Pyran-4-Yl)-1H-Pyrazolo[3,4-D]Pyrimidine is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyrimidine class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel, targeted therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and development, particularly within oncology and kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Biochemical Tool Compound: Used in vitro to study enzyme inhibition mechanisms and cellular signaling pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of active pharmaceutical ingredients (APIs).
• Academic Research: Employed in university and institutional labs for exploratory synthetic chemistry and biological evaluation projects.

Basic Information

Product Name	6-Chloro-1-(Tetrahydro-Pyran-4-Yl)-1H-Pyrazolo[3,4-D]Pyrimidine
CAS No.	1443286-90-5
Molecular Formula	C10H11ClN4O
Molecular Weight	238.67 g/mol
Synonyms	6-Chloro-1-(oxan-4-yl)-1H-pyrazolo[3,4-d]pyrimidine; 1-(Tetrahydro-2H-pyran-4-yl)-6-chloro-1H-pyrazolo[3,4-d]pyrimidine; 6-Chloro-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidine; 1443286-90-5; 6-Chloro-1-tetrahydropyran-4-yl-1H-pyrazolo[3,4-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 6-Chloro-1-(Tetrahydro-Pyran-4-Yl)-1H-Pyrazolo[3,4-D]Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for prolonged operations to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.