Description

4-Difluoromethyl-Pyrimidine-5-Carboxylic Acid Methyl Ester is a high-value fluorinated pyrimidine building block essential for advanced organic synthesis. This compound is critical for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms can dramatically alter biological activity and metabolic stability. It is primarily sought after by the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of fluorinated drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides where fluorination enhances lipophilicity and target binding.
• Chemical Biology Probe: Serves as a building block for creating fluorinated probes and inhibitors to study enzyme mechanisms and biological pathways.
• Material Science Precursor: Potential use in the synthesis of advanced organic materials, such as ligands for catalysis or components for electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific fluorinated heterocycles.

Basic Information

Product Name	4-Difluoromethyl-Pyrimidine-5-Carboxylic Acid Methyl Ester
CAS No.	1443286-01-8
Molecular Formula	C8H6F2N2O2
Molecular Weight	200.14 g/mol
Synonyms	Methyl 4-(difluoromethyl)pyrimidine-5-carboxylate; 5-Pyrimidinecarboxylic acid, 4-(difluoromethyl)-, methyl ester; 4-(Difluoromethyl)pyrimidine-5-carboxylic acid methyl ester; Methyl 4-(difluoromethyl)-5-pyrimidinecarboxylate
EINECS	Contact for details

Quality Control

Our 4-Difluoromethyl-Pyrimidine-5-Carboxylic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.