Description

Benzyl 5H-Pyrrolo[3,4-D]Pyrimidine-6(7H)-Carboxylate CAS NO 1440526-54-4 is a high-purity, advanced pharmaceutical intermediate belonging to the fused pyrrolopyrimidine class of heterocyclic compounds. This compound is of significant value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in oncology and kinase inhibitor research. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of targeted kinase inhibitors and other small-molecule drugs.
• Oncology Research: Serves as a core scaffold for developing novel anti-cancer compounds due to its pyrrolopyrimidine structure, which mimics purine bases.
• Chemical Biology & Proteomics: Used in the design and synthesis of chemical probes for studying enzyme function and signal transduction pathways.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of candidate drugs.
• Academic Research: Utilized in universities and research institutes for medicinal chemistry projects and heterocyclic compound library synthesis.
• Custom Synthesis: A starting material for the custom manufacturing of bespoke molecules for client-specific drug discovery programs.

Basic Information

Product Name	Benzyl 5H-Pyrrolo[3,4-D]Pyrimidine-6(7H)-Carboxylate
CAS No.	1440526-54-4
Molecular Formula	C14H13N3O2
Molecular Weight	255.27 g/mol
Synonyms	6-Benzyloxycarbonyl-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine; Benzyl 5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate; 6H-Pyrrolo[3,4-d]pyrimidine-6-carboxylic acid, 5,7-dihydro-, phenylmethyl ester; 6-CBz-5,7-dihydropyrrolo[3,4-d]pyrimidine; 6-Benzyl 5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate; Bn-6H-PP-6-COOEt (common abbreviation); Pyrrolo[3,4-d]pyrimidine-6-carboxylate benzyl ester
EINECS	Contact for details

Quality Control

Our Benzyl 5H-Pyrrolo[3,4-D]Pyrimidine-6(7H)-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards expected for GMP-grade intermediates used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.