Description

2-Methyl-7,8-Dihydro-5H-Pyrido[4,3-D]Pyrimidine-6-Carboxylic Acid Benzyl Ester is a high-value pharmaceutical intermediate and chemical building block of significant interest in modern organic synthesis. This compound matters for its role as a key precursor in the development of active pharmaceutical ingredients (APIs), particularly within kinase inhibitor research and other therapeutic areas. Pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers are the primary industrial users who need this material for advanced drug discovery and process development programs.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the multi-step synthesis of novel drug candidates, especially kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Chemical Biology Probes: Employed in the development of tool compounds for studying biological pathways and target validation.
• Process Chemistry Development: Utilized for scaling up synthetic routes and optimizing manufacturing processes for potential APIs.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic Research: Used in university and institutional labs for pioneering research in heterocyclic and medicinal chemistry.

Basic Information

Product Name	2-Methyl-7,8-Dihydro-5H-Pyrido[4,3-D]Pyrimidine-6-Carboxylic Acid Benzyl Ester
CAS No.	1440526-52-2
Molecular Formula	C16H17N3O2
Molecular Weight	283.33 g/mol
Synonyms	Benzyl 2-methyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate; 5H-Pyrido[4,3-d]pyrimidine-6-carboxylic acid, 7,8-dihydro-2-methyl-, phenylmethyl ester; 2-Methyl-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylic acid benzyl ester (tautomeric form); Pyrido[4,3-d]pyrimidine benzyl ester derivative; CAS 1440526-52-2
EINECS	Contact for details

Quality Control

Our production of 2-Methyl-7,8-Dihydro-5H-Pyrido[4,3-D]Pyrimidine-6-Carboxylic Acid Benzyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical R&D. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and prolonged exposure to air; for long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.