Description

4-Chloromethyl-2-Phenyl-Pyrimidine-5-Carboxylic Acid Ethyl Ester is a high-value pyrimidine-based building block and key synthetic intermediate. This compound matters for its crucial role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and advanced agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for synthesizing novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potential drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require a functionalized pyrimidine core.
• Chemical Research & Development: Serves as a versatile building block for constructing diverse heterocyclic libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Material Science Precursor: Potential use in the synthesis of organic ligands for metal-organic frameworks (MOFs) or functional polymers.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring specific pyrimidine derivatives.

Basic Information

Product Name	4-Chloromethyl-2-Phenyl-Pyrimidine-5-Carboxylic Acid Ethyl Ester
CAS No.	1440526-40-8
Molecular Formula	C15H15ClN2O2
Molecular Weight	290.74 g/mol
Synonyms	Ethyl 4-(chloromethyl)-2-phenylpyrimidine-5-carboxylate; 2-Phenyl-4-chloromethyl-pyrimidine-5-carboxylic acid ethyl ester; 4-(Chloromethyl)-2-phenyl-5-pyrimidinecarboxylic acid ethyl ester; 4-Chloromethyl-2-phenyl-5-ethoxycarbonylpyrimidine; CAS 1440526-40-8
EINECS	Contact for details

Quality Control

Our 4-Chloromethyl-2-Phenyl-Pyrimidine-5-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to the reactive chloromethyl group, it should be stored separately from strong bases and nucleophiles.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.