Description

2-Amino-7,8-Dihydro-5H-Pyrido[4,3-D]Pyrimidine-6-Carboxylic Acid Benzyl Ester CAS NO 1440526-34-0 is a high-purity, advanced pharmaceutical intermediate characterized by its fused pyridopyrimidine core structure. This compound is of significant value for research and development in medicinal chemistry, serving as a critical building block for the synthesis of novel therapeutic agents. It is primarily sought after by pharmaceutical companies, biotechnology research firms, and contract development and manufacturing organizations (CDMOs) engaged in the discovery of new drug candidates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex small-molecule drugs targeting various disease pathways.
• Kinase Inhibitor Development: The pyridopyrimidine scaffold is a privileged structure in the design of potent and selective kinase inhibitors for oncology and inflammatory diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to improve drug-like properties.
• Chemical Biology Probes: Serves as a core structure for developing tool compounds to study specific biological targets and mechanisms.
• Custom Synthesis: Employed by CDMOs for the contract manufacturing of proprietary drug substances at various development stages.
• Academic Research: Utilized in university and institutional labs for fundamental research in heterocyclic chemistry and drug discovery methodologies.

Basic Information

Item	Details
Product Name	2-Amino-7,8-Dihydro-5H-Pyrido[4,3-D]Pyrimidine-6-Carboxylic Acid Benzyl Ester
CAS No.	1440526-34-0
Molecular Formula	C15H16N4O2
Molecular Weight	284.31 g/mol
Synonyms	Benzyl 2-amino-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-6-carboxylate; 2-Amino-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-6-carboxylic acid benzyl ester; 1440526-34-0; UNII-9K1W8V6A2I; 9K1W8V6A2I; SCHEMBL21806227; AKOS040759232; ZINC000003869937
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-7,8-Dihydro-5H-Pyrido[4,3-D]Pyrimidine-6-Carboxylic Acid Benzyl Ester is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity, meeting the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.