Description

tert-Butyl 4-(2,6-Dichloropyrimidin-4-Yl)Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperidine core protected by a Boc (tert-butoxycarbonyl) group and a dichloropyrimidine moiety. This compound is a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas such as oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Development: The dichloropyrimidine scaffold is a privileged structure in the design of potent and selective kinase inhibitors for cancer therapy.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns to explore new chemical entities.
• Boc-Protected Amine Chemistry: Serves as a versatile intermediate where the Boc group can be selectively deprotected to reveal the secondary amine for further functionalization.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	tert-Butyl 4-(2,6-Dichloropyrimidin-4-Yl)Piperidine-1-Carboxylate
CAS No.	1439823-01-4
Molecular Formula	C14H17Cl2N3O2
Molecular Weight	330.21 g/mol
Synonyms	1-Boc-4-(2,6-dichloropyrimidin-4-yl)piperidine; 4-(2,6-Dichloro-4-pyrimidinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(2,6-dichloro-4-pyrimidinyl)-1-piperidinecarboxylate; 1-(tert-Butoxycarbonyl)-4-(2,6-dichloropyrimidin-4-yl)piperidine; 4-(2,6-Dichloropyrimidin-4-yl)piperidine-1-carboxylic acid tert-butyl ester; BOC-4-(2,6-Dichloro-pyrimidin-4-yl)-piperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(2,6-Dichloropyrimidin-4-Yl)Piperidine-1-Carboxylate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development use. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards and can provide material tailored to specific project requirements, including custom purity grades.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.