Description

2-Fluoro-3-(trifluoromethoxy)phenyl acetate is a high-purity fluorinated aromatic ester building block of significant interest in advanced organic synthesis. This compound is valued for its unique molecular architecture, which incorporates both fluorine and a trifluoromethoxy group, enabling precise modulation of electronic and steric properties in target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for constructing bioactive molecules, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorinated motif enhances biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Advanced Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed reactions (e.g., Suzuki, Stille) for creating complex biaryl structures.
• Chemical Biology Probes: Utilized in the design of fluorinated probes and tags for studying biological processes and protein interactions.

Basic Information

Product Name	2-Fluoro-3-(trifluoromethoxy)phenyl acetate
CAS No.	1437794-81-4
Molecular Formula	C9H6F4O3
Molecular Weight	238.14 g/mol
Synonyms	1-Acetoxy-2-fluoro-3-(trifluoromethoxy)benzene; [2-Fluoro-3-(trifluoromethoxy)phenyl] acetate; 2-Fluoro-3-trifluoromethoxyphenyl acetate; Acetic acid 2-fluoro-3-(trifluoromethoxy)phenyl ester; 2-Fluoro-α,α,α-trifluoro-m-cresyl acetate
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-3-(trifluoromethoxy)phenyl acetate is manufactured under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC-MS, and NMR to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.