Description

Thieno[2,3-D]Pyrimidine-3(2H)-Acetic Acid, 6-Carboxy-1,4-Dihydro-α,α,5-Trimethyl-2,4-Dioxo-, 3-(1,1-Dimethylethyl) Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development for targeted therapies.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of complex drug candidates, especially those targeting specific enzymatic pathways.
• Drug Discovery & Development: Used in medicinal chemistry research for constructing thienopyrimidine-based libraries to screen for new biological activity.
• Active Pharmaceutical Ingredient (API) Synthesis: A key raw material in the production route for final API molecules, where its ester group allows for further functionalization.
• Biochemical Research: Employed as a standard or reference compound in studies investigating the structure-activity relationships (SAR) of heterocyclic compounds.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis methodology development.

Basic Information

Product Name	Thieno[2,3-D]Pyrimidine-3(2H)-Acetic Acid, 6-Carboxy-1,4-Dihydro-α,α,5-Trimethyl-2,4-Dioxo-, 3-(1,1-Dimethylethyl) Ester
CAS No.	1434643-23-8
Molecular Formula	C18H22N2O6S
Molecular Weight	394.44 g/mol
Synonyms	3-(tert-Butyl) 6-carboxy-1,4-dihydro-α,α,5-trimethyl-2,4-dioxothieno[2,3-d]pyrimidine-3(2H)-acetate; tert-Butyl 2-(6-carboxy-1,4-dihydro-α,α,5-trimethyl-2,4-dioxothieno[2,3-d]pyrimidin-3(2H)-yl)acetate; Thieno[2,3-d]pyrimidine-3(2H)-acetic acid, 6-carboxy-1,4-dihydro-α,α,5-trimethyl-2,4-dioxo-, 1,1-dimethylethyl ester; CAS 1434643-23-8; Thienopyrimidine derivative ester; 6-Carboxythienopyrimidine tert-butyl ester
EINECS	Contact for details

Quality Control

Our Thieno[2,3-D]Pyrimidine-3(2H)-Acetic Acid, 6-Carboxy-1,4-Dihydro-α,α,5-Trimethyl-2,4-Dioxo-, 3-(1,1-Dimethylethyl) Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and cGMP manufacturing. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled and stored accordingly to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.