Description

3,5-Dichloro-4-(Trifluoromethyl)Benzenamine Hydrochloride is a high-purity, halogenated aniline derivative hydrochloride salt, serving as a critical advanced pharmaceutical intermediate and versatile building block in organic synthesis. Its value lies in its unique molecular architecture, combining electron-withdrawing chloro and trifluoromethyl groups, which is essential for modulating the biological activity and physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients, as well as by fine chemical manufacturers producing specialized materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: A versatile reagent for Suzuki, Buchwald-Hartwig, and other cross-coupling reactions to create complex, multi-substituted aromatic systems.
• Dye and Pigment Intermediate: Utilized in the synthesis of specialized dyes and pigments where halogen and fluorine substituents alter color fastness and spectral properties.

Basic Information

Item	Detail
Product Name	3,5-Dichloro-4-(Trifluoromethyl)Benzenamine Hydrochloride
CAS No.	1432795-16-8
Molecular Formula	C7H5Cl2F3N • HCl
Molecular Weight	270.93 g/mol (Free base: 234.03 g/mol)
Synonyms	3,5-Dichloro-4-(trifluoromethyl)aniline hydrochloride; 4-Amino-2,6-dichlorobenzotrifluoride hydrochloride; 2,6-Dichloro-4-(trifluoromethyl)aniline hydrochloride; Benzenamine, 3,5-dichloro-4-(trifluoromethyl)-, hydrochloride; 3,5-Dichloro-α,α,α-trifluoro-p-toluidine hydrochloride; 4-(Trifluoromethyl)-3,5-dichloroaniline hydrochloride
EINECS	Contact for details

Quality Control

Every batch of 3,5-Dichloro-4-(Trifluoromethyl)Benzenamine Hydrochloride is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, NMR, and other relevant spectroscopic and chromatographic methods. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.