Description

(E)-4-(5-Fluoropyrimidin-2-Yl)But-3-En-2-One CAS NO 1432793-64-0 is a high-purity fluorinated pyrimidine derivative, serving as a critical advanced pharmaceutical intermediate. Its core value lies in enabling the synthesis of novel, targeted drug candidates, particularly in oncology and antiviral research. This compound is essential for medicinal chemistry research and development teams in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel small-molecule drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies due to its fluoropyrimidine core, a privileged scaffold in drug discovery.
• Oncology Drug Development: Integral in the research and development of potential anti-cancer agents, leveraging the biological activity of fluoropyrimidine motifs.
• Antiviral Agent Synthesis: Serves as a precursor in the development of new antiviral compounds, where pyrimidine analogs are commonly explored.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, complex organic molecules.
• Agrochemical Research: Potential intermediate in the development of new active ingredients for crop protection, given the utility of fluorinated heterocycles.

Basic Information

Product Name	(E)-4-(5-Fluoropyrimidin-2-Yl)But-3-En-2-One
CAS No.	1432793-64-0
Molecular Formula	C9H7FN2O
Molecular Weight	178.16 g/mol
Synonyms	(E)-4-(5-Fluoropyrimidin-2-yl)but-3-en-2-one; 4-(5-Fluoropyrimidin-2-yl)-3-buten-2-one; 3-Buten-2-one, 4-(5-fluoro-2-pyrimidinyl)-, (E)-; (E)-4-(5-Fluor-2-pyrimidinyl)-3-buten-2-on; 2-(3-Oxobut-1-en-1-yl)-5-fluoropyrimidine; 5-Fluoro-2-[(1E)-3-oxo-1-buten-1-yl]pyrimidine; (E)-1-(5-Fluoropyrimidin-2-yl)prop-2-en-1-one (tautomeric form)
EINECS	Contact for details

Quality Control

Our (E)-4-(5-Fluoropyrimidin-2-Yl)But-3-En-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.