Description

Fmoc-Sdma(Boc)2-Ona CAS NO 1429484-34-3 is a protected amino acid derivative, specifically an Fmoc-protected symmetric dimethylarginine with tert-butyloxycarbonyl (Boc) groups on the guanidino nitrogens. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled incorporation of post-translationally modified arginine residues. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and biotechnology who require high-purity, sequence-defined peptides for drug discovery and biochemical studies.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of peptides containing symmetric dimethylarginine (SDMA) residues.
• Pharmaceutical R&D: For the development of peptide-based therapeutics targeting protein-protein interactions, epigenetics, and signal transduction pathways where arginine methylation plays a role.
• Biochemical Research: Used to prepare defined peptide substrates or inhibitors for studying methylarginine-specific enzymes like protein arginine methyltransferases (PRMTs) and readers.
• Proteomics Standards: Synthesis of internal standards and reference peptides for mass spectrometry-based quantification of protein methylation states.
• Antibody Production: Creation of immunogenic peptides for generating antibodies specific to methylated arginine epitopes.

Basic Information

Product Name	Fmoc-Sdma(Boc)2-Ona
CAS No.	1429484-34-3
Molecular Formula	C₃₃H₄₅N₅O₈
Molecular Weight	639.75 g/mol
Synonyms	Fmoc-Sym-dimethylarginine(Boc)2-OH; N-α-Fmoc-NG,NG'-di-Boc-symmetric dimethyl-L-arginine; Fmoc-NG,NG'-di-Boc-SDMA-OH; Fmoc-SDMA(Boc)2-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-NG,NG'-bis[(tert-butoxy)carbonyl]-Nδ,Nδ-dimethyl-L-ornithine; Fmoc-L-Symmetric dimethylarginine(Boc)2; Fmoc-Sym(NG,NG'-Boc2)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-Sdma(Boc)2-Ona is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive synthetic applications. We employ advanced analytical techniques including HPLC, LC-MS, and NMR to verify identity, purity, and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each batch to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	≥ 95.0%
Optical Rotation	-15.0° to -25.0° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.