Description

(R)-3-(2-Chloropyrimidin-4-Yl)-4-Phenyloxazolidin-2-One CAS NO 1429180-77-7 is a high-purity, chiral oxazolidinone derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with specific stereochemistry, which is essential for developing active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of novel therapeutics, particularly in areas requiring precise chiral control.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Asymmetric Synthesis: Used as an auxiliary or building block in stereoselective chemical reactions to introduce the (R)-configuration into target molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore novel chemical space.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for potential Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the synthesis of specialized compounds for studying biological pathways and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital component for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	(R)-3-(2-Chloropyrimidin-4-Yl)-4-Phenyloxazolidin-2-One
CAS No.	1429180-77-7
Molecular Formula	C₁₃H₁₀ClN₃O₂
Molecular Weight	275.69 g/mol
Synonyms	(R)-3-(2-Chloro-4-pyrimidinyl)-4-phenyl-2-oxazolidinone; (4R)-3-(2-Chloropyrimidin-4-yl)-4-phenyl-1,3-oxazolidin-2-one; (R)-4-Phenyl-3-(2-chloropyrimidin-4-yl)oxazolidin-2-one; 2-Oxazolidinone, 3-(2-chloro-4-pyrimidinyl)-4-phenyl-, (4R)-; (R)-2-Oxazolidinone, 3-(2-chloro-4-pyrimidinyl)-4-phenyl-; (R)-enantiomer of 3-(2-Chloropyrimidin-4-Yl)-4-Phenyloxazolidin-2-One
EINECS	Contact for details

Quality Control

Our (R)-3-(2-Chloropyrimidin-4-Yl)-4-Phenyloxazolidin-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and enantiomeric purity suitable for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.