Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl His(Trt)-Gly-Oh is a protected amino acid derivative, specifically a Fmoc-His(Trt)-Gly-OH dipeptide building block, essential for solid-phase peptide synthesis (SPPS). This compound matters for its role in enabling the precise and efficient construction of complex peptides and proteins, particularly those containing histidine and glycine residues, by providing orthogonal protection for the imidazole side chain. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected dipeptide building block for the automated or manual synthesis of custom peptide sequences.
• Pharmaceutical Research: For the research and development of novel peptide-based therapeutics, including hormone analogs, antimicrobial peptides, and targeted drug conjugates.
• Bioconjugation: Serving as a precursor for creating peptide tags or linkers used to conjugate biomolecules to surfaces, nanoparticles, or other proteins.
• Chemical Biology Probes: Incorporation into peptides designed as enzyme substrates, inhibitors, or probes to study biological mechanisms and protein-protein interactions.
• Process Development: Used in scaling up the production of specific peptide sequences for preclinical and clinical studies.
• Academic Research: A fundamental reagent in university and institutional labs for training and fundamental studies in peptide chemistry and biochemistry.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl His(Trt)-Gly-Oh
CAS No.	1428125-83-0
Molecular Formula	C47H42N4O5
Molecular Weight	742.87 g/mol
Synonyms	Fmoc-His(Trt)-Gly-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N'-(trityl)-L-histidylglycine; Fmoc-L-histidine(Nim-trityl)-glycine; Fmoc-His(Trt)-Gly; Nα-Fmoc-Nim-trityl-L-histidylglycine; Fmoc-His(Trityl)-Gly-OH; (9-Fluorenylmethoxycarbonyl)-histidyl(trityl)-glycine; Fmoc-His(Trt)-Glycine
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl His(Trt)-Gly-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for peptide synthesis applications. Certificates of Analysis (COA) detailing purity (by HPLC), chiral purity, and identity are provided with every shipment. We can support compliance with relevant standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.