Description

6-Chloro-n-((1R,2S)-2-(3,4-Difluorophenyl)Cyclopropyl)-5- Nitro-2-(Propylthio)Pyrimidin-4-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its complex, multi-functional heterocyclic structure. This compound is of significant commercial importance for its role in the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of investigational new drugs, especially those targeting specific enzyme or receptor pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its unique pyrimidine core and chiral cyclopropyl group.
• API Development: Serves as a critical precursor in the multi-step synthesis of potential active pharmaceutical ingredients for clinical trials.
• Chemical Biology Probes: Utilized in the development of specialized molecular probes for studying biological mechanisms and target validation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific custom synthesis projects.

Basic Information

Product Name	6-Chloro-n-((1R,2S)-2-(3,4-Difluorophenyl)Cyclopropyl)-5- Nitro-2-(Propylthio)Pyrimidin-4-Amine
CAS No.	1427523-93-0
Molecular Formula	C16H15ClF2N4O2S
Molecular Weight	400.83 g/mol
Synonyms	6-Chloro-N-[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]-5-nitro-2-(propylsulfanyl)pyrimidin-4-amine; (1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamine derivative; 5-Nitro-6-chloro-2-(propylthio)pyrimidin-4-amine cyclopropyl intermediate; CAS 1427523-93-0; Difluorophenyl cyclopropyl pyrimidine amine; Nitro-chloro-propylthio pyrimidine intermediate
EINECS	Contact for details

Quality Control

Our 6-Chloro-n-((1R,2S)-2-(3,4-Difluorophenyl)Cyclopropyl)-5- Nitro-2-(Propylthio)Pyrimidin-4-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity limits is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.