Description

4-Difluoromethyl-Pyrimidine-5-Carbonitrile is a high-value, multi-functional heterocyclic building block characterized by its pyrimidine core, difluoromethyl group, and nitrile functionality. This compound is essential for medicinal chemistry and agrochemical research, enabling the rapid synthesis of novel molecules with enhanced biological activity and metabolic stability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and antiviral agents.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the difluoromethyl group can improve lipophilicity and bioavailability.
• Material Science Precursor: Serves as a building block for functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes in CDMO (Contract Development and Manufacturing Organization) facilities.

Basic Information

Product Name	4-Difluoromethyl-Pyrimidine-5-Carbonitrile
CAS No.	1427195-45-6
Molecular Formula	C6H3F2N3
Molecular Weight	155.11 g/mol
Synonyms	5-Cyano-4-(difluoromethyl)pyrimidine; 4-(Difluoromethyl)pyrimidine-5-carbonitrile; Pyrimidine-5-carbonitrile, 4-(difluoromethyl)-; 1427195-45-6; 4-Difluoromethyl-5-cyanopyrimidine
EINECS	Contact for details

Quality Control

Our production of 4-Difluoromethyl-Pyrimidine-5-Carbonitrile adheres to stringent quality management protocols. Every batch is analyzed using advanced techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality system is designed to support cGMP (current Good Manufacturing Practice) requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.