Description

4-(1,1-Difluoro-Ethyl)-Pyrimidine-5-Carbaldehyde is a high-purity, fluorinated pyrimidine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecular architectures, particularly for applications demanding specific fluorine substitution patterns. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to synthesize novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoroethyl group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the development of organic electronic materials, such as components for OLEDs or semiconductors, where fluorinated heterocycles can tune electronic properties.
• Chemical Biology Probes: Useful for synthesizing labeled compounds or probes for studying biological mechanisms and target engagement.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Item	Detail
Product Name	4-(1,1-Difluoro-Ethyl)-Pyrimidine-5-Carbaldehyde
CAS No.	1427195-32-1
Molecular Formula	C7H6F2N2O
Molecular Weight	172.13 g/mol
Synonyms	5-Formyl-4-(1,1-difluoroethyl)pyrimidine; 4-(1,1-Difluoroethyl)pyrimidine-5-carboxaldehyde; 4-(Difluoroethyl)-5-pyrimidinecarboxaldehyde; 4-(1,1-Difluoroethyl)-5-pyrimidinecarbaldehyde; Pyrimidine-5-carbaldehyde, 4-(1,1-difluoroethyl)-; 1427195-32-1
EINECS	Contact for details

Quality Control

Our 4-(1,1-Difluoro-Ethyl)-Pyrimidine-5-Carbaldehyde is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to quality supports compliance in cGMP environments for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged storage or when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.