Description

(4-(2-Fluoropropan-2-Yl)Pyrimidin-5-Yl)Methanamine Hydrochloride CAS NO 1427195-20-7 is a high-purity, advanced pharmaceutical intermediate featuring a fluorinated pyrimidine scaffold. This compound is of significant value for medicinal chemistry research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing novel drug candidates, especially in oncology and antiviral fields.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization campaigns due to its fluorinated isopropyl and amine functional groups.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degradation molecules.
• Kinase Inhibitor Synthesis: A critical precursor for the development of selective kinase inhibitors, leveraging the pyrimidine core's affinity for ATP-binding sites.
• Chemical Biology Probes: Utilized in the creation of chemical probes for studying specific biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	(4-(2-Fluoropropan-2-Yl)Pyrimidin-5-Yl)Methanamine Hydrochloride
CAS No.	1427195-20-7
Molecular Formula	C8H13ClFN3
Molecular Weight	205.66 g/mol
Synonyms	5-(Aminomethyl)-4-(2-fluoro-2-propanyl)pyrimidine hydrochloride; 1-(4-(2-Fluoropropan-2-yl)pyrimidin-5-yl)methanamine hydrochloride; (4-(2-Fluoroisopropyl)pyrimidin-5-yl)methanamine HCl; 4-(2-Fluoro-2-propyl)pyrimidine-5-methanamine hydrochloride; 5-(Aminomethyl)-4-(1-fluoro-1-methylethyl)pyrimidine hydrochloride; 1427195-20-7; (4-(2-Fluoropropan-2-yl)-5-pyrimidinyl)methanamine hydrochloride
EINECS	Contact for details

Quality Control

Our (4-(2-Fluoropropan-2-Yl)Pyrimidin-5-Yl)Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. For advanced applications, we can supply material produced under controlled environments suitable for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.