Description

2-(4-Piperazin-1-Yl-Phenyl)-Pyrimidine Dihydrochloride is a high-purity, dihydrochloride salt derivative of a piperazinyl-phenyl-pyrimidine scaffold, a structure of significant interest in modern pharmaceutical research. This compound serves as a critical advanced pharmaceutical intermediate or building block for the synthesis of novel drug candidates. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates targeting various disease pathways.
• Kinase Inhibitor Research: Used in the development and screening of novel kinase inhibitors due to its privileged heterocyclic structure.
• Chemical Biology Probes: Serves as a core structure for creating molecular probes to study protein function and cellular signaling.
• Medicinal Chemistry Optimization: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of lead compounds.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Used in university and institutional labs for fundamental research in organic chemistry and drug discovery.

Basic Information

Item	Details
Product Name	2-(4-Piperazin-1-Yl-Phenyl)-Pyrimidine Dihydrochloride
CAS No.	1427195-19-4
Molecular Formula	C14H17N5·2HCl
Molecular Weight	328.24 g/mol (free base: 255.32 g/mol)
Synonyms	2-[4-(Piperazin-1-yl)phenyl]pyrimidine dihydrochloride; 2-(4-Piperazin-1-ylphenyl)pyrimidine hydrochloride (1:2); 1427195-19-4; UNII-7K3I4WY4QO; 7K3I4WY4QO; 2-(4-Piperazin-1-yl-phenyl)-pyrimidine dihydrochloride; 2-(4-(Piperazin-1-yl)phenyl)pyrimidine dihydrochloride; AKOS025310584; CS-0336220
EINECS	Contact for details

Quality Control

Our 2-(4-Piperazin-1-Yl-Phenyl)-Pyrimidine Dihydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed results from HPLC, NMR, and mass spectrometry. Our quality standards are designed to meet the stringent requirements of pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.