Description

1-(Pyrimidin-2-Yl)Cyclopropane-1-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclopropane-carboxylic acid scaffold fused with a pyrimidine heterocycle. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel small-molecule therapeutics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to incorporate this privileged structure into new active compounds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of potential drug candidates targeting various diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in bifunctional degrader molecules.
• Agrochemical Synthesis: Intermediate in the development of new herbicides, fungicides, or insecticides with novel modes of action.
• Chemical Biology Probes: Utilized to create tool compounds for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring this specific molecular architecture.

Basic Information

Product Name	1-(Pyrimidin-2-Yl)Cyclopropane-1-Carboxylic Acid
CAS No.	1427022-89-6
Molecular Formula	C8H8N2O2
Molecular Weight	164.16 g/mol
Synonyms	1-(2-Pyrimidinyl)cyclopropanecarboxylic acid; 1-(Pyrimidin-2-yl)cyclopropanecarboxylic acid; Cyclopropanecarboxylic acid, 1-(2-pyrimidinyl)-; 1-Pyrimidin-2-ylcyclopropanecarboxylic acid; 1427022-89-6; 1-(2-Pyrimidinyl)cyclopropane-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(Pyrimidin-2-Yl)Cyclopropane-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high standards in research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.