Description

(Des-Gly10,D-Tyr5,D-Trp6,Pro-Nhet9)-Lhrh CAS NO 1426173-46-7 is a synthetic peptide analog of Luteinizing Hormone-Releasing Hormone (LHRH), engineered with specific amino acid substitutions to enhance its stability and biological activity profile. This compound is critical for advanced research in endocrinology and the development of targeted therapeutic strategies. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroendocrinology, oncology, and reproductive medicine.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel hormone-based therapies.
• Endocrinology Studies: For investigating the structure-activity relationships (SAR) of LHRH analogs and their interaction with gonadotropin-releasing hormone (GnRH) receptors.
• Oncology Research: Exploration of applications in cancers that are hormone-sensitive, such as prostate and breast cancer, due to its modified receptor binding properties.
• Biochemical Assay Development: Used as a high-purity ligand in competitive binding assays and other in vitro diagnostic tests.
• Peptide Chemistry & Synthesis: Serves as a sophisticated building block or template for the synthesis of more complex peptide conjugates and libraries.
• Veterinary Pharmaceutical Development: Potential use in developing fertility control and hormonal treatments in animals.

Basic Information

Product Name	(Des-Gly10,D-Tyr5,D-Trp6,Pro-Nhet9)-Lhrh
CAS No.	1426173-46-7
Molecular Formula	C58H78N16O12
Molecular Weight	1151.3 g/mol (approx.)
Synonyms	Des-Gly10,D-Tyr5,D-Trp6,Pro-NHEt9-LHRH; LHRH Analog (Des-Gly10, D-Tyr5, D-Trp6, Pro-NHEt9); GnRH Antagonist Analog; pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt; Modified Luteinizing Hormone-Releasing Hormone Fragment; Gonadorelin Analog; Peptide LHRH Antagonist; [Des-Gly10, D-Tyr5, D-Trp6, Pro-NHEt9]-LHRH
EINECS	Contact for details

Quality Control

Our (Des-Gly10,D-Tyr5,D-Trp6,Pro-Nhet9)-Lhrh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture uptake. For short-term use, store at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 8.0%
Peptide Content (AAA)	≥ 80.0%
Acetate Content (HPLC)	≤ 15.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.