Description

Fmoc-(Dmb)Leu-Oh CAS NO 1425938-65-3 is a protected amino acid derivative, specifically an Fmoc-protected leucine with an acid-labile 2,4-dimethoxybenzyl (Dmb) side-chain protecting group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is primarily used by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, diagnostic reagents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the Fmoc-strategy synthesis of peptides containing leucine, particularly where orthogonal side-chain protection is required.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates, including hormones, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation and Protein Engineering: Used to introduce modified leucine residues into synthetic peptides for subsequent labeling, cross-linking, or functionalization.
• Combinatorial Chemistry Libraries: Serves as a building block in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Academic & Institutional Research: Essential for biochemical and biophysical studies requiring custom-designed peptides with specific protective group strategies.
• Production of Peptide Reference Standards: Used in the manufacture of high-purity peptide standards for analytical methods like HPLC and mass spectrometry.

Basic Information

Product Name	Fmoc-(Dmb)Leu-Oh
CAS No.	1425938-65-3
Molecular Formula	C28H29NO6
Molecular Weight	475.53 g/mol
Synonyms	Fmoc-Leu(2,4-OMe-Bzl)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(2,4-dimethoxybenzyl)-L-leucine; Fmoc-L-leucine(2,4-dimethoxybenzyl) ester; Fmoc-Leu(Dmb)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-[(2,4-dimethoxyphenyl)methoxy]-4-methylpentanoic acid; Nα-Fmoc-Nε-(2,4-dimethoxybenzyl)-L-leucine; Fmoc-L-Leu(Dmb)-OH; Protected Leucine Derivative
EINECS	Contact for details

Quality Control

Our Fmoc-(Dmb)Leu-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.