Description

(4S)-3-(Fmoc-Thr(Tbu))-2,2-Dimethyl-Oxazolidine-4-Carboxylic Acid is a sophisticated, orthogonally protected amino acid derivative designed for advanced peptide synthesis. This compound matters because it provides critical protection for the threonine side chain and α-amino group, enabling precise and efficient construction of complex peptide sequences. Pharmaceutical researchers and fine chemical manufacturers need this high-purity building block for the development of therapeutic peptides, peptidomimetics, and other bioactive molecules where sequence integrity is paramount.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the automated synthesis of peptides containing threonine residues.
• Solution-Phase Peptide Synthesis: Used in classical coupling strategies for constructing specific peptide fragments or smaller sequences.
• Pharmaceutical Research & Development: Serves as a critical building block in the discovery and development of novel peptide-based therapeutics and diagnostics.
• Peptidomimetic Design: Employed in the synthesis of modified peptide structures that mimic natural peptides but with enhanced stability or activity.
• Combinatorial Chemistry Libraries: Used to introduce protected threonine moieties into diverse compound libraries for high-throughput screening.
• Academic Research: A valuable reagent for studies in organic chemistry, medicinal chemistry, and biochemistry focused on peptide structure and function.

Basic Information

Product Name	(4S)-3-(Fmoc-Thr(Tbu))-2,2-Dimethyl-Oxazolidine-4-Carboxylic Acid
CAS No.	1425938-63-1
Molecular Formula	C30H38N2O7
Molecular Weight	538.64 g/mol
Synonyms	Fmoc-Thr(tBu)-OH (Oxazolidine); N-α-Fmoc-O-tert-butyl-L-threonine (Oxazolidine); (4S)-3-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2,2-dimethyl-4-[(2S)-2-[(2-methylpropan-2-yl)oxy]butanoyl]oxazolidine-4-carboxylic acid; Fmoc-L-threonine(O-t-butyl) derivative (cyclic); Fmoc-Thr(OtBu)-OH (cyclic form); Protected Fmoc-Threonine derivative; Oxazolidine-protected Fmoc amino acid
EINECS	Contact for details

Quality Control

Our (4S)-3-(Fmoc-Thr(Tbu))-2,2-Dimethyl-Oxazolidine-4-Carboxylic Acid is manufactured under strict quality systems to ensure the high purity and consistency required for sensitive synthetic applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.