Description

D-Alanine, 3-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-n-Methyl- is a sophisticated, non-natural amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound is critical for introducing specific, modified alanine residues into peptide chains, enabling the study of structure-activity relationships and the development of novel bioactive molecules. It is an essential building block for pharmaceutical R&D, particularly in the development of peptide-based therapeutics, diagnostic agents, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc/Boc-protected amino acid building block for the controlled assembly of complex peptides.
• Medicinal Chemistry & Drug Discovery: For the research and development of novel peptide drugs, including antimicrobial peptides and hormone analogs.
• Bioconjugation & Probe Development: Used to create labeled peptides for imaging, diagnostic assays, and target identification studies.
• Chemical Biology Research: Employed to investigate protein-protein interactions, enzyme mechanisms, and receptor binding by incorporating modified amino acids.
• Process Development & Scale-Up: Serves as a critical intermediate in the GMP-compliant manufacturing of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	D-Alanine, 3-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-n-Methyl-
CAS No.	1424972-75-7
Molecular Formula	C24H28N2O6
Molecular Weight	440.49 g/mol
Synonyms	Fmoc-N-Me-3-(Boc-amino)-D-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-3-[[(1,1-dimethylethoxy)carbonyl]amino]-D-alanine; Nα-Fmoc-Nα-methyl-3-(N-Boc-amino)-D-alanine; Boc-NH-CH(COOH)-N(Me)-Fmoc (D-isomer); Fmoc-N-Me-D-Ala(3-Boc-NH)-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-((tert-butoxycarbonyl)amino)propanoic acid; D-3-(Boc-Amino)-N-Fmoc-N-methylalanine; N-Fmoc-N-methyl-3-(N-Boc-amino)-D-alanine
EINECS	Contact for details

Quality Control

Every batch of this advanced amino acid derivative is produced and tested under strict quality management protocols to ensure consistency and purity for sensitive research and development applications. Our standard specification typically meets or exceeds 95% purity (by HPLC), with rigorous controls for chiral purity and moisture content. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment. We support development projects requiring custom specifications or GMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This material is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.