Description

Dde-Orn(Fmoc)-Oh is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound matters because it provides critical control over the selective deprotection of side-chain functional groups, enabling the synthesis of complex peptides and peptide conjugates. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and proteomics who require high-purity building blocks for constructing challenging peptide sequences. The product is supplied to exacting standards to ensure reliable performance in sensitive applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for the controlled incorporation of ornithine with orthogonal side-chain protection.
• Pharmaceutical Research & Development: For the synthesis of peptide-based drug candidates, vaccines, and diagnostic agents.
• Bioconjugation: Enables the site-specific attachment of labels, tags, or payloads to peptides and proteins.
• Combinatorial Chemistry: Used in libraries for high-throughput screening of bioactive peptides.
• Glycopeptide & Lipopeptide Synthesis: Facilitates the construction of complex modified peptides where selective deprotection is required.
• Academic Research: A vital tool in biochemistry and chemical biology laboratories studying protein-protein interactions and peptide structure-activity relationships.

Basic Information

Product Name	Dde-Orn(Fmoc)-Oh
CAS No.	1423017-87-1
Molecular Formula	C₂₆H₂₉N₃O₆
Molecular Weight	479.53 g/mol
Synonyms	Nα-Fmoc-Nδ-Dde-L-ornithine; Fmoc-Orn(Dde)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)amino)pentanoic acid; Nδ-(1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)-Nα-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-ornithine; Fmoc-L-Orn(Dde)-OH; Nα-Fmoc-Nδ-(4,4-dimethyl-2,6-dioxocyclohexylidene-3-methylbutyl)-L-ornithine
EINECS	Contact for details

Quality Control

Every batch of Dde-Orn(Fmoc)-Oh undergoes rigorous analytical testing to ensure it meets the high-purity standards required for peptide synthesis. Our quality control protocols include multiple orthogonal methods to verify identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing lot-specific results from HPLC, NMR, and MS are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-20° to -25° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.