Description

(3R)-1-(Pyrimidin-2-Yl)Pyrrolidin-3-Amine Hydrochloride is a high-purity chiral amine hydrochloride salt, serving as a critical building block in modern pharmaceutical research and development. Its value lies in its role as a sophisticated intermediate for constructing complex molecules, particularly in the synthesis of targeted therapeutics. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries working on novel drug candidates, including kinase inhibitors and other small-molecule therapies.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Process Chemistry: Serves as a starting material or advanced intermediate in the scale-up and commercial synthesis of targeted therapeutics.
• Kinase Inhibitor Synthesis: Particularly valuable for constructing pyrrolidine-pyrimidine based scaffolds common in kinase inhibitor development.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective synthesis routes.
• Chemical Biology: Employed in the design and synthesis of molecular probes for studying biological pathways.

Basic Information

Product Name	(3R)-1-(Pyrimidin-2-Yl)Pyrrolidin-3-Amine Hydrochloride
CAS No.	1421025-59-3
Molecular Formula	C8H13N5·HCl
Molecular Weight	215.68 g/mol
Synonyms	(R)-1-(Pyrimidin-2-yl)pyrrolidin-3-amine hydrochloride; (3R)-1-Pyrimidin-2-ylpyrrolidin-3-amine hydrochloride; (R)-3-Amino-1-(pyrimidin-2-yl)pyrrolidine hydrochloride; 1-(Pyrimidin-2-yl)-(3R)-pyrrolidin-3-amine HCl; UNII-9K9S2F1F2V; 9K9S2F1F2V; (R)-1-(2-Pyrimidinyl)-3-pyrrolidinamine hydrochloride; (R)-N1-(Pyrimidin-2-yl)pyrrolidine-1,3-diamine hydrochloride
EINECS	Contact for details

Quality Control

Our (3R)-1-(Pyrimidin-2-Yl)Pyrrolidin-3-Amine Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, and our quality control protocols include validated analytical methods such as HPLC, chiral HPLC, and NMR to meet the stringent requirements of our global clientele.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.