Description

(R)-3-(4-Ethylamino-Pyrimidin-2-Yloxy)-Piperidine-1-Carboxylic Acid is a high-purity chiral piperidine derivative, a crucial advanced pharmaceutical intermediate (API) for targeted drug development. Its value lies in its role as a sophisticated building block for synthesizing novel, potent, and selective therapeutic agents, particularly in oncology and central nervous system (CNS) research. This compound is essential for pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and innovators developing next-generation small molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel kinase inhibitors and other targeted cancer therapies.
• Drug Discovery & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Preclinical Research: Serves as a critical component for producing compounds for in vitro and in vivo pharmacological evaluation.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the final synthetic steps for producing clinical trial materials and commercial drug substances.
• Chemical Biology Probes: Utilized to create tool compounds for studying specific biological pathways and target validation.

Basic Information

Product Name	(R)-3-(4-Ethylamino-Pyrimidin-2-Yloxy)-Piperidine-1-Carboxylic Acid
CAS No.	1421020-83-8
Molecular Formula	C13H20N4O3
Molecular Weight	280.33 g/mol
Synonyms	1-Piperidinecarboxylic acid, 3-[(4-(ethylamino)-2-pyrimidinyl)oxy]-, (3R)-; (R)-3-((4-(Ethylamino)pyrimidin-2-yl)oxy)piperidine-1-carboxylic acid; (3R)-3-{[4-(Ethylamino)pyrimidin-2-yl]oxy}piperidine-1-carboxylic acid; UNII-9Y3G9F8A4M; 9Y3G9F8A4M; (R)-enantiomer of 3-(4-Ethylamino-pyrimidin-2-yloxy)-piperidine-1-carboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-3-(4-Ethylamino-Pyrimidin-2-Yloxy)-Piperidine-1-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific client or regulatory requirements, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere if specified. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.