Description

tert-Butyl n-[(3S)-1-(Pyrimidin-2-Yl)Pyrrolidin-3-Yl]Carbamate is a high-purity, chiral organic intermediate of significant importance in modern pharmaceutical synthesis. Its core value lies in its role as a key building block for constructing complex molecules with specific three-dimensional configurations, which are critical for developing active pharmaceutical ingredients (APIs). This compound is essential for research and development chemists and process scale-up teams working in the pharmaceutical and biotechnology industries, particularly in the areas of targeted drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Process Chemistry & Scale-Up: Used in the development and optimization of scalable synthetic routes for Active Pharmaceutical Ingredients (APIs) under Good Manufacturing Practice (GMP) guidelines.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery.
• Asymmetric Synthesis: Employed in reactions requiring high enantiomeric purity due to its defined (3S) stereochemistry.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations (CROs/CMOs) for custom synthesis projects.
• Reference Standard: Can be utilized as a high-purity analytical standard for method development and quality control in API production.

Basic Information

Product Name	tert-Butyl n-[(3S)-1-(Pyrimidin-2-Yl)Pyrrolidin-3-Yl]Carbamate
CAS No.	1421019-15-9
Molecular Formula	C13H20N4O2
Molecular Weight	264.33 g/mol
Synonyms	tert-Butyl (3S)-1-(pyrimidin-2-yl)pyrrolidin-3-ylcarbamate; (3S)-1-(Pyrimidin-2-yl)pyrrolidin-3-amine, N-Boc-protected; Boc-L-1-(2-Pyrimidyl)-3-aminopyrrolidine; (S)-tert-Butyl (1-(pyrimidin-2-yl)pyrrolidin-3-yl)carbamate; N-Boc-3(S)-Amino-1-(2-pyrimidyl)pyrrolidine; 1421019-15-9; (S)-3-((tert-Butoxycarbonyl)amino)-1-(pyrimidin-2-yl)pyrrolidine
EINECS	Contact for details

Quality Control

Our tert-Butyl n-[(3S)-1-(Pyrimidin-2-Yl)Pyrrolidin-3-Yl]Carbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification tests, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. Comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.