Description

(1-(5-Fluoropyrimidin-2-Yl)Piperidin-3-Yl)Methanamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS number 1420880-86-9. This compound is of significant value in medicinal chemistry for its role as a key building block in the synthesis of novel therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of small molecule drugs, particularly those targeting kinase inhibition and other critical biological pathways.

Application

• Pharmaceutical Intermediate: A critical building block in the research and synthesis of novel active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Development: Serves as a core scaffold for the design and optimization of potent and selective kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore new chemical entities for various disease targets.
• Preclinical Drug Candidate Synthesis: Essential for producing gram to kilogram quantities of lead compounds for pharmacological evaluation.
• Chemical Biology Probes: Can be utilized to create tool compounds for studying specific biological processes and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.

Basic Information

Product Name	(1-(5-Fluoropyrimidin-2-Yl)Piperidin-3-Yl)Methanamine Hydrochloride
CAS No.	1420880-86-9
Molecular Formula	C10H14FN5·HCl
Molecular Weight	259.71 g/mol (Free base: 223.25 g/mol)
Synonyms	1-(5-Fluoropyrimidin-2-yl)piperidin-3-ylmethanamine hydrochloride; 3-(Aminomethyl)-1-(5-fluoropyrimidin-2-yl)piperidine hydrochloride; 1-(5-Fluoro-2-pyrimidinyl)-3-piperidinemethanamine hydrochloride; (1-(5-Fluoropyrimidin-2-yl)piperidin-3-yl)methanamine HCl; 1420880-86-9; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our (1-(5-Fluoropyrimidin-2-Yl)Piperidin-3-Yl)Methanamine Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring the material meets the exacting standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) for long-term storage to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.