Description

Fmoc-D-Dab(Mtt)-Oh is a protected amino acid derivative essential for advanced solid-phase peptide synthesis (SPPS). This compound is specifically engineered to provide orthogonal protection for the side chain of D-2,4-diaminobutyric acid (D-Dab), enabling the precise and sequential construction of complex peptides. It is a critical building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled incorporation of D-2,4-diaminobutyric acid residues using Fmoc chemistry protocols.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs, including antimicrobial peptides, hormone analogs, and targeted therapeutics.
• Peptide Library Construction: Enables the synthesis of diverse peptide libraries for high-throughput screening in drug discovery and biochemical assays.
• Bioconjugation: Serves as a specialized linker or spacer molecule for attaching peptides to other biomolecules, surfaces, or reporter groups.
• Structural Biology Studies: Facilitates the synthesis of custom peptides used to study protein-protein interactions, enzyme mechanisms, and receptor binding.
• Production of Modified Peptides: Essential for creating peptides with site-specific modifications, isotopic labels, or fluorescent tags for advanced research applications.

Basic Information

Product Name	Fmoc-D-Dab(Mtt)-Oh
CAS No.	1419640-31-5
Molecular Formula	C41H38N2O5
Molecular Weight	638.75 g/mol
Synonyms	Fmoc-D-2,4-diaminobutyric acid(Mtt)-OH; N-α-Fmoc-N-δ-(4-methyltrityl)-D-2,4-diaminobutyric acid; Fmoc-D-Dab(4-Mtt)-OH; Fmoc-D-Dab(Mtt)-OH CAS 1419640-31-5; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-4-[[4-methylphenyl)-diphenylmethyl]amino]butanoic acid; N-δ-(4-Methyltrityl)-N-α-(9-fluorenylmethoxycarbonyl)-D-2,4-diaminobutyric Acid; Fmoc-D-Dab(4-Methyltrityl)-OH
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for peptide synthesis. Every batch is characterized using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing purity (by HPLC), chiral purity, and other critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% D-isomer
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.