Description

Ethyl 7-Boc-2-Chloro-5,6,7,8-Tetrahydropyrido-[4,3-D]Pyrimidine-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected amine and a reactive chloro-pyrimidine core. This compound is critical for the synthesis of complex small-molecule therapeutics, particularly kinase inhibitors, due to its versatile functional handles for further derivatization. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery and process development for oncology and other therapeutic areas.

Application

• Key Intermediate in Kinase Inhibitor Synthesis: Serves as a crucial building block for the development of potent and selective kinase inhibitors targeting various cancer pathways.
• Pharmaceutical Research & Development (R&D): Used in medicinal chemistry for lead optimization and the creation of novel compound libraries.
• Process Chemistry & Scale-Up: Employed in the development and optimization of scalable synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of targeted therapies under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) and novel heterocyclic chemistry.

Basic Information

Product Name	Ethyl 7-Boc-2-Chloro-5,6,7,8-Tetrahydropyrido-[4,3-D]Pyrimidine-4-Carboxylate
CAS No.	1419101-04-4
Molecular Formula	C₁₅H₂₀ClN₃O₄
Molecular Weight	341.79 g/mol
Synonyms	Ethyl 2-chloro-7-(tert-butoxycarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-carboxylate; 7-Boc-2-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine-4-carboxylic acid ethyl ester; 1419101-04-4; tert-Butyl 2-chloro-4-(ethoxycarbonyl)-5,8-dihydropyrido[4,3-d]pyrimidine-7(6H)-carboxylate; BOC-protected chloropyridopyrimidine carboxylate.
EINECS	Contact for details

Quality Control

Our Ethyl 7-Boc-2-Chloro-5,6,7,8-Tetrahydropyrido-[4,3-D]Pyrimidine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.