Description

4-(1-(Trifluoromethyl)Cyclopropyl)Benzaldehyde is a high-purity, advanced pharmaceutical intermediate featuring a unique trifluoromethylcyclopropyl-benzaldehyde scaffold. This compound is valued for its role in modulating the physicochemical properties of target molecules, particularly enhancing metabolic stability and lipophilicity. It is primarily sought after by R&D and process chemistry teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the development of advanced organic electronic materials, contributing to the molecular design of charge-transport or emissive layers.
• Cross-Coupling Reactions: The aldehyde functional group makes it a suitable substrate for various palladium-catalyzed cross-coupling and condensation reactions to construct complex biaryl systems.
• Fluorine Chemistry Research: An important reagent for studying the influence of the rigid, lipophilic trifluoromethylcyclopropyl moiety on molecular conformation and binding affinity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from gram to kilogram quantities.

Basic Information

Product Name	4-(1-(Trifluoromethyl)Cyclopropyl)Benzaldehyde
CAS No.	1418297-04-7
Molecular Formula	C11H9F3O
Molecular Weight	214.18 g/mol
Synonyms	4-[1-(Trifluoromethyl)cyclopropyl]benzaldehyde; 4-(1-Trifluoromethylcyclopropyl)benzaldehyde; Benzaldehyde, 4-[1-(trifluoromethyl)cyclopropyl]-; 1418297-04-7; p-(1-(Trifluoromethyl)cyclopropyl)benzaldehyde; 4-(Trifluoromethylcyclopropyl)benzaldehyde; 1-[4-Formylphenyl]-1-(trifluoromethyl)cyclopropane
EINECS	Contact for details

Quality Control

Every batch of 4-(1-(Trifluoromethyl)Cyclopropyl)Benzaldehyde is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.