Description

2-Chloro-4-(Piperidin-4-Ylmethoxy)-Pyrimidine Hydrochloride is a high-purity pharmaceutical intermediate and building block of significant importance in modern organic synthesis. This compound matters for its critical role as a key precursor in the development of novel, small-molecule therapeutics, particularly kinase inhibitors. Pharmaceutical R&D teams and fine chemical manufacturers need this material for its precise chemical structure, which enables the construction of complex molecules targeting specific biological pathways.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of targeted kinase inhibitors for oncology and inflammatory disease research.
• Chemical Synthesis Reagent: Used in cross-coupling reactions, nucleophilic substitutions, and other advanced organic transformations to introduce the pyrimidine-piperidine scaffold.
• Medicinal Chemistry Research: Serves as a core structural motif for constructing compound libraries in drug discovery and lead optimization programs.
• Active Pharmaceutical Ingredient (API) Development: Employed in the late-stage synthesis and process development of candidate drug molecules.
• Biochemical Tool Compound: Used in the development of probes for studying enzyme function and cellular signaling pathways.
• Contract Manufacturing & Development (CDMO): Supplied to CDMOs for the cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	2-Chloro-4-(Piperidin-4-Ylmethoxy)-Pyrimidine Hydrochloride
CAS No.	1417793-06-6
Molecular Formula	C10H15ClN3O • HCl
Molecular Weight	264.16 g/mol (Free base: 227.70 g/mol)
Synonyms	2-Chloro-4-[(4-piperidinyl)methoxy]pyrimidine hydrochloride; 4-[(2-Chloropyrimidin-4-yl)oxy]methylpiperidine hydrochloride; 2-Chloro-4-(piperidin-4-ylmethoxy)pyrimidine HCl; 2-Chloro-4-(4-piperidylmethoxy)pyrimidine hydrochloride; Pyrimidine, 2-chloro-4-[(4-piperidinyl)methoxy]-, hydrochloride; 1417793-06-6
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-(Piperidin-4-Ylmethoxy)-Pyrimidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are available for every shipment. We support development and commercial projects requiring material traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.