Description

(S)-3-(4-Ethylamino-Pyrimidin-2-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it provides a critical, stereochemically defined building block for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor research. Pharmaceutical R&D and process chemistry teams need it for constructing complex molecular architectures where the specific (S)-configuration at the pyrrolidine center is essential for biological activity and drug efficacy.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of targeted kinase inhibitors and other small molecule therapeutics.
• Preclinical & Clinical API Development: Used in research and development for constructing candidate drug molecules during lead optimization and scale-up studies.
• Process Chemistry & Route Scouting: Serves as a validated starting material for exploring efficient synthetic pathways to complex heterocyclic targets.
• Asymmetric Synthesis Building Block: Utilized in medicinal chemistry to introduce the pyrrolidine-oxypyrimidine pharmacophore with high enantiomeric purity.
• Contract Manufacturing (CMO): Supplied to contract research and manufacturing organizations for GMP and non-GMP production of advanced intermediates.
• Chemical Reference Standard: Can be provided as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	(S)-3-(4-Ethylamino-Pyrimidin-2-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1417789-70-8
Molecular Formula	C15H24N4O3
Molecular Weight	308.38 g/mol
Synonyms	1-tert-Butyl (3S)-3-[(4-ethylamino)pyrimidin-2-yl]oxy]pyrrolidine-1-carboxylate; tert-Butyl (S)-3-((4-(ethylamino)pyrimidin-2-yl)oxy)pyrrolidine-1-carboxylate; (S)-1-Boc-3-((4-(ethylamino)pyrimidin-2-yl)oxy)pyrrolidine; (S)-3-[4-(Ethylamino)-2-pyrimidinyl]oxy]-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; Boc-protected (S)-3-(4-ethylaminopyrimidin-2-yloxy)pyrrolidine; (S)-3-(4-Ethylamino-pyrimidin-2-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (S)-3-(4-Ethylamino-Pyrimidin-2-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and NMR for structural confirmation, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.