Description

(R)-2-Chloro-1-[3-(6-Cyclopropylamino-Pyrimidin-4-Yloxy)-Pyrrolidin-1-Yl]-Ethanone is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial interest. Its value lies in its specific stereochemistry and functional groups, which are critical for the synthesis of targeted bioactive molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those working on novel kinase inhibitors or other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for targeted therapies.
• Kinase Inhibitor Synthesis: Serves as a critical precursor in the construction of potent and selective kinase inhibitors due to its pyrimidine and pyrrolidine motifs.
• Agrochemical Research: Used in the development of new active ingredients for crop protection, leveraging its heterocyclic structure.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and cellular signaling pathways.
• Process Chemistry & Scale-Up: Provides a defined stereocenter for process optimization and the commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Custom Synthesis & Contract Manufacturing: A valuable starting material for fine chemical suppliers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	(R)-2-Chloro-1-[3-(6-Cyclopropylamino-Pyrimidin-4-Yloxy)-Pyrrolidin-1-Yl]-Ethanone
CAS No.	1417789-60-6
Molecular Formula	C14H19ClN4O2
Molecular Weight	310.78 g/mol
Synonyms	(R)-2-Chloro-1-(3-((6-(cyclopropylamino)pyrimidin-4-yl)oxy)pyrrolidin-1-yl)ethanone; (R)-2-Chloro-1-(3-(6-(cyclopropylamino)pyrimidin-4-yloxy)pyrrolidin-1-yl)ethanone; UNII-2P4Q2T9R3U; 2P4Q2T9R3U; Ethanone, 2-chloro-1-[3-[[6-(cyclopropylamino)-4-pyrimidinyl]oxy]-1-pyrrolidinyl]-, (R)-; AOB67717; CS-0536225; (R)-2-Chloro-1-(3-(6-(cyclopropylamino)pyrimidin-4-yloxy)pyrrolidin-1-yl)ethan-1-one
EINECS	Contact for details

Quality Control

Our production of (R)-2-Chloro-1-[3-(6-Cyclopropylamino-Pyrimidin-4-Yloxy)-Pyrrolidin-1-Yl]-Ethanone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm identity, potency, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.