Description

Ethyl-[2-((R)-Piperidin-3-Yloxy)-Pyrimidin-4-Yl]-Amine Hydrochloride is a high-purity, non-racemic chiral building block and pharmaceutical intermediate of significant interest in modern medicinal chemistry. This compound is valued for its structural complexity, which incorporates a pyrimidine core linked to a chiral piperidine moiety, enabling the synthesis of targeted bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Serves as a crucial building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Synthesis: Used in the preparation of potential kinase inhibitors, leveraging the pyrimidine scaffold's affinity for ATP-binding sites.
• CNS-Targeted Drug Development: Employed in the synthesis of compounds targeting neurological receptors and pathways due to the pharmacophore's characteristics.
• Preclinical Candidate Synthesis: Integral in the scale-up synthesis of candidates for preclinical and early-phase clinical trials.
• Custom Synthesis & Contract Manufacturing: Supplied for custom synthesis projects requiring high-purity, complex chiral intermediates.

Basic Information

Product Name	Ethyl-[2-((R)-Piperidin-3-Yloxy)-Pyrimidin-4-Yl]-Amine Hydrochloride
CAS No.	1417788-96-5
Molecular Formula	C11H19ClN4O
Molecular Weight	258.75 g/mol
Synonyms	4-Pyrimidinamine, 2-[(3R)-3-piperidinyloxy]-N-ethyl-, hydrochloride (1:1); (R)-Ethyl-(2-(piperidin-3-yloxy)pyrimidin-4-yl)amine hydrochloride; N-Ethyl-2-((R)-piperidin-3-yloxy)pyrimidin-4-amine hydrochloride; 2-((R)-Piperidin-3-yloxy)-N-ethylpyrimidin-4-amine HCl; 1417788-96-5; UNII-Contact for details
EINECS	Contact for details

Quality Control

Our Ethyl-[2-((R)-Piperidin-3-Yloxy)-Pyrimidin-4-Yl]-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.