Description

3,5-Difluoro-4-(trifluoromethyl)benzaldehyde is a high-value fluorinated aromatic aldehyde building block, essential for introducing specific steric and electronic properties into advanced molecular architectures. Its unique structure, featuring both difluoro and trifluoromethyl substituents, makes it a critical intermediate for synthesizing compounds with enhanced metabolic stability, lipophilicity, and binding affinity. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases where fluorination improves drug-like properties.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms contribute to weatherfastness, membrane permeability, and biological activity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated liquid crystal molecules and organic light-emitting diode (OLED) materials, where its structure helps fine-tune electronic properties and thermal stability.
• Polymer & Functional Material Modifier: Incorporated into specialty polymers and coatings to impart specific characteristics such as chemical resistance, low surface energy, and optical clarity.
• Cross-Coupling Reactions: The aldehyde group is amenable to further transformations (e.g., reductive amination, condensation) to create complex biaryl systems and heterocycles common in medicinal chemistry.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating libraries of fluorinated compounds for screening.

Basic Information

Product Name	3,5-Difluoro-4-(trifluoromethyl)benzaldehyde
CAS No.	1417569-98-2
Molecular Formula	C8H3F5O
Molecular Weight	210.10 g/mol
Synonyms	4-(Trifluoromethyl)-3,5-difluorobenzaldehyde; 3,5-Difluoro-4-(trifluoromethyl)benzaldehyde; 4-(Trifluoromethyl)-3,5-difluorobenzenecarboxaldehyde; Benzaldehyde, 3,5-difluoro-4-(trifluoromethyl)-; 3,5-Difluoro-alpha,alpha,α-trifluoro-p-tolualdehyde; 1417569-98-2
EINECS	Contact for details

Quality Control

Our production of 3,5-Difluoro-4-(trifluoromethyl)benzaldehyde adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to verify identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP and ISO 9001 standards for pharmaceutical and industrial customers, ensuring full traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from strong oxidizing agents, strong bases, and reducing agents. For long-term storage, consider storage under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.