Description

7-(Trifluoromethyl)Benzo[D][1,3]Dioxole-5-Carbaldehyde is a high-value fluorinated aromatic aldehyde building block, characterized by its benzo[d][1,3]dioxole (methylenedioxybenzene) core and a strategically positioned trifluoromethyl group. This unique molecular architecture makes it a critical intermediate for synthesizing advanced compounds where enhanced lipophilicity, metabolic stability, and electronic properties are required. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in central nervous system (CNS) and oncology research, where the trifluoromethyl and methylenedioxy groups can modulate bioavailability and receptor binding.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve weatherfastness and biological activity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: An essential reagent for medicinal and synthetic chemistry, enabling structure-activity relationship (SAR) studies and the exploration of novel chemical space.
• Fluorine Chemistry: A valuable substrate for further functionalization via the aldehyde group, allowing for the creation of a diverse library of trifluoromethyl-containing derivatives for screening.

Basic Information

Product Name	7-(Trifluoromethyl)Benzo[D][1,3]Dioxole-5-Carbaldehyde
CAS No.	1417353-80-0
Molecular Formula	C9H5F3O3
Molecular Weight	218.13 g/mol
Synonyms	5-Formyl-7-(trifluoromethyl)-1,3-benzodioxole; 7-(Trifluoromethyl)-1,3-benzodioxole-5-carboxaldehyde; 7-(Trifluoromethyl)benzo[d][1,3]dioxole-5-carbaldehyde; 7-Trifluoromethylbenzo[1,3]dioxole-5-carbaldehyde; 5-Carbaldehyde-7-trifluoromethylbenzo[d][1,3]dioxole; 7-Trifluoromethyl-1,3-benzodioxole-5-carbaldehyde
EINECS	Contact for details

Quality Control

Every batch of 7-(Trifluoromethyl)Benzo[D][1,3]Dioxole-5-Carbaldehyde is manufactured and tested under a strict quality management system. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.