Description

H-Cys(Npys)-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Nh2 is a synthetic, cell-penetrating peptide (CPP) derivative featuring a reactive nitropyridinesulfenyl (Npys) group on the N-terminal cysteine residue. This compound is specifically engineered for the covalent conjugation of cargo molecules, such as drugs, proteins, or imaging agents, to facilitate their efficient intracellular delivery. It is a critical research tool for scientists in pharmaceutical development, biochemistry, and cell biology who are investigating novel therapeutic delivery platforms and studying intracellular processes.

Application

• Intracellular Drug Delivery: Conjugation of therapeutic agents (e.g., oligonucleotides, small molecules, peptides) to the CPP sequence for enhanced cellular uptake and bioavailability.
• Protein Transduction Research: Facilitating the study of protein function by enabling the delivery of full-length proteins or functional domains into living cells.
• Molecular Imaging Probe Delivery: Transport of fluorescent dyes, quantum dots, or other imaging agents across cell membranes for live-cell microscopy and diagnostic applications.
• Bioconjugation & Linker Chemistry: The reactive Npys group serves as a specific thiol-reactive handle for creating stable disulfide linkages with other biomolecules.
• Development of Cell-Penetrating Peptide (CPP) Libraries: Used as a key building block or reference compound in the design and screening of novel CPP sequences.
• Gene Therapy Vector Enhancement: Investigation into improving the efficiency of non-viral gene delivery systems by peptide-mediated membrane translocation.

Basic Information

Product Name	H-Cys(Npys)-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Nh2
CAS No.	1417221-06-7
Molecular Formula	C78H155N45O13S2
Molecular Weight	~1995.4 g/mol
Synonyms	Cys(Npys)-(Arg)9-NH2; Npys-Cys-(Arg)9-NH2; CPP (Arg9) Npys derivative; Polyarginine (R9) Npys peptide; Nitropyridinesulfenyl-Cys-Arg9-amide; Cell-penetrating peptide (9R) with N-terminal Npys; H-Cys(3-nitro-2-pyridinesulfenyl)-nonarginine amide; Thiol-reactive nona-arginine peptide
EINECS	Contact for details

Quality Control

Our H-Cys(Npys)-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Nh2 is manufactured under strict quality systems to ensure batch-to-batch consistency for research applications. Each lot undergoes comprehensive analytical characterization. Certificates of Analysis (COA) are provided, detailing purity, identity, and other critical parameters as determined by HPLC, MS, and other relevant techniques.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Assay (Peptide Content)	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.