Description

1H-Isoindol-1-One, 7-Bromo-2,3-Dihydro-2-[2-[3-(2-Pyrimidinyl)Phenyl]Ethyl]- is a high-purity, advanced pharmaceutical intermediate (API intermediate) characterized by its complex heterocyclic structure. This compound matters for its critical role in the research and development of novel small-molecule therapeutics, particularly in kinase inhibitor programs. Pharmaceutical R&D teams and fine chemical manufacturers need this precise building block to enable the synthesis of targeted drug candidates with potential applications in oncology and other therapeutic areas.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of kinase inhibitors and other targeted therapies.
• Organic Synthesis Building Block: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Biochemical Research: Employed as a reference standard or probe compound in biological assay development and target validation.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of novel chemical entities.
• Academic Research: Utilized in university and institutional labs for pioneering research in heterocyclic and medicinal chemistry.

Basic Information

Product Name	1H-Isoindol-1-One, 7-Bromo-2,3-Dihydro-2-[2-[3-(2-Pyrimidinyl)Phenyl]Ethyl]-
CAS No.	1417190-47-6
Molecular Formula	C20H16BrN3O
Molecular Weight	394.27 g/mol
Synonyms	7-Bromo-2-[2-[3-(pyrimidin-2-yl)phenyl]ethyl]-2,3-dihydro-1H-isoindol-1-one; 7-Bromo-2-(2-(3-(pyrimidin-2-yl)phenyl)ethyl)isoindolin-1-one; 1417190-47-6; BRD-K4477; BRD K4477; BRDK4477; CAS 1417190-47-6
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing all critical quality attributes. We support our clients' regulatory needs with documentation suitable for use in pre-clinical and development-phase applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.